B6db activities : lmbs

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	lmbs
Description	GDP-D-α-D-lincosamide aminotransferase (2.6.1.-)
Alternative names	CcbS (gene name); LmbS (gene name)
Catalyzed reaction	GDP-D-α-D-lincosamide + 2-oxoglutarate <=> GDP-6-oxo 6(1-hydroxyethyl)galactose + glutamate
Cofactor	Pyridoxal phosphate.
Comments	GDP-D-α-D-lincosamide [i.e., GDP-6-amino 6(1-hydroxyethyl)galactose] is an intermediate in the formation of lyncomycin antibiotics in Streptomyces lincolnensis. The enzyme LmbS (and also its homolog CcbS, from the Celesticetin biosynthesis pathway) catalyzes the reaction in the direction opposite to the one shown above.
Organisms	-Eubacteria

Links	Enzyme (activities) lmbs BRENDA (activities) lmbs KEGG (pathways) lmbs PLPMDB (PLP mutants) lmbs

References	Wang SA, Lin CI, Zhang J, Ushimaru R, Sasaki E, Liu HW (2020) Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A Proc Natl Acad Sci U S A 117 24794-24801. Articles on lmbs

last changed	2020/11/04 15:48