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B6db activities: marg

Description beta-methyltriptophan aminotransferase (2.6.1.-)
Catalyzed reaction beta-methyl-L-triptophan + + 2-oxoglutarate = beta-methyl-beta-indole-pyruvate + L-glutamate
Cofactor Pyridoxal-phosphate
Comments The physiological reaction occurs in the opposite direction. Can use both stereoisomers of β-methyl-indolepyruvate, producing either (2S,3R)-β-methyltryptophan or (2S,3S)-β-methyltryptophan. It can also act as a tryptophan aminotransferase (EC
beta-methyltriptophan is a biosynthetic precursor of bioactive natural products such as maremycin A and B.
Organisms -Eubacteria


marg (0)
Links Enzyme (activities) marg
BRENDA (activities) marg
KEGG (pathways) marg
PLPMDB (PLP mutants) marg
 Zou Y1, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S. (2013) Stereospecific biosynthesis of β-methyltryptophan from (L)-tryptophan features a stereochemical switch Angew Chem Int Ed Engl 52 12951-5.

Articles on marg
last changed 2017/09/08 08:52

B6db activities