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mppp |
Description |
Arginine 4-hydroxylase/deaminase (1.13.12.-) |
Alternative names |
MppP (gene name);
RohP (gene name)
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Catalyzed reaction |
L-arginine + 2O(2)+2H(2)O = (S)-4-hydroxy-2-ketoarginine + H(2)O(2) |
Cofactor |
Pyridoxal phosphate |
Comments |
The enzyme from S. waydamensis is involved in the Enduracididine Biosynthetic Pathway.
It yields a mixture of 2-oxo-4-hydroxy-5-guanidinovalerate and 2-oxo-5-guanidinovalerate in a 1.7:1 ratio.
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PDB |
5DJ1; 6C3B; |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) mppp
BRENDA (activities) mppp
KEGG (pathways) mppp
PLPMDB (PLP mutants) mppp
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References |
Han L, Vuksanovic N, Oehm SA, Fenske TG, Schwabacher AW, Silvaggi N. (2018) Streptomyces wadayamensis MppP is a PLP-dependent oxidase, not an oxygenase Biochemistry 57 3252-3264. Hedges JB, Kuatsjah E, Du YL, Eltis LD, Ryan KS. (2018) Snapshots of the catalytic cycle of an O2, pyridoxal phosphate-dependent hydroxylase. ACS Chem Biol 13 965-974. Han L, Schwabacher AW, Moran GR, Silvaggi NR (2015) Streptomyces wadayamensis MppP Is a Pyridoxal 5'-Phosphate-Dependent L-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway Biochemistry 54 7029-40. Articles on mppp |
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last changed |
2019/06/20 13:09 |
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