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o_succinylhomoserine_sulfhydrylase |
Description |
O-succinylhomoserine sulfhydrylase (2.5.1.-) |
Alternative names |
O-succinylhomoserine(thiol)-lyase (ambiguous). |
Catalyzed reaction |
O-succinyl-L-homoserine + H2S = L-homocysteine + succinate. |
Cofactor |
Pyridoxal-phosphate. |
Comments |
This enzyme is involved in one of the possible pathways for the biosynthesis of methionine.
Cystathionine gamma-synthase (O-succynilhomoserine (thiol)-lyase, EC 2.5.1.48) catalyzes this reaction, too, but the two validated genes encoding O-succinylhomoserine-sulfhydrylase (from Pseudomonas and Rhizobium) are clearly distinct from those encoding EC 2.5.1.48. |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) o_succinylhomoserine_sulfhydrylase
BRENDA (activities) o_succinylhomoserine_sulfhydrylase
KEGG (pathways) o_succinylhomoserine_sulfhydrylase
PLPMDB (PLP mutants) o_succinylhomoserine_sulfhydrylase
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References |
Tate, R.; Riccio, A.; Caputo, E.; Iaccarino, M.; Patriarca, E. J. (1999) The Rhizobium etli metZ gene is essential for methionine biosynthesis and nodulation of Phaseolus vulgaris Mol Plant Microbe Interact 12 24-34. Vermeij P, Kertesz MA. (1999) Pathways of assimilative sulfur metabolism in Pseudomonas putida J Bacteriol 181 5833-7. Foglino, M.; Borne, F.; Bally, M.; Ball, G.; Patte, J. C. (1995) A direct sulfhydrylation pathway is used for methionine biosynthesis in Pseudomonas aeruginosa Microbiology 141 431-9. Articles on o.succinylhomoserine.sulfhydrylase |
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last changed |
2019/06/20 18:13 |
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