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odcp |
Description |
Ornithine decarboxylase paralogue |
Alternative names |
ornithine decarboxylase antizyme inhibitor; ODCp; ODCp2;
AZIN1 (gene name);
AZIN2 (gene name)
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Catalyzed reaction |
None - This is a nonenzymatic homologue of ornithine decarboxylase. |
Comments |
These metazoan proteins belonging to the fold-type III group were once attributed an arginine decarboxylase function. However, subsequent studies proved that they are not catalytic, but rather regulatory proteins. |
PDB |
4ZGZ; |
Organisms |
-Metazoa |
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Family |
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Links |
Enzyme (activities) odcp
BRENDA (activities) odcp
KEGG (pathways) odcp
PLPMDB (PLP mutants) odcp
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References |
Rajput B, Murphy TD, Pruitt KD (2015) RefSeq curation and annotation of antizyme and antizyme inhibitor genes in vertebrates Nucleic Acids Res 43 7270-9. Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC. (2008) Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase Biochem J 409 187-92. López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R. (2006) Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity J Biol Chem 281 30896-906. Zhu, MY.; Iyo, A.; Piletz, J.E.; Regunathan, S. (2004) Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine Biochim Biophys Acta 1670 156-64. Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S. (1997) Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor Biochim Biophys Acta 1353 209-16. Articles on odcp |
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last changed |
2018/07/18 14:45 |
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