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ovob |
Description |
S-(4'-L-histidyl)-L-cysteine sulfoxide lyase (4.4.1.-) |
Alternative names |
sulfoxide lyase; Beta C-S lyase. |
Catalyzed reaction |
S-(4'-L-histidyl)-L-cysteine sulfoxide = mercaptohistidine + NH(3) + pyruvate. |
Cofactor |
Pyridoxal-phosphate. |
Comments |
The sulfoxide lyase is responsible for mercaptohistidine production, an intermediate of the Ovothiol A Biosynthesis. |
PDB |
5Z0Q; |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) ovob
BRENDA (activities) ovob
KEGG (pathways) ovob
PLPMDB (PLP mutants) ovob
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References |
Naowarojna N, Huang P, Cai Y, Song H, Wu L, Cheng R, Li Y, Wang S, Lyu H, Zhang L, Zhou J, Liu P. (2018) In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions. Org Lett. 20 5427-5430. Vogt RN, Spies HS, Steenkamp DJ. (2001) The biosynthesis of ovothiol A (N-methyl-4-mercaptohistidine). Identification of S-(4'-L-histidyl)-L-cysteine sulfoxide as an intermediate and the products of the sulfoxide lyase reaction. Eur J Biochem. 268 5229-41. Articles on ovob |
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last changed |
2019/06/20 13:11 |
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