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B6db activities: oxyq

Description (S)-4-amino-anhydrotetracycline transaminase ( 2.6.1.-)
Alternative names 4-oxo-anhydrotetracycline transaminase;
OxyQ (gene name)
Catalyzed reaction 4-oxo-anhydrotetracycline + an L-amino acid = (S)-4-amino-anhydrotetracycline + a 2-oxo acid
Cofactor Pyridoxal-phosphate.
The aminotransferase OxyQ catalyzes the amination of C4-keto of 4-oxo-anhydrotetracycline, yielding 4-amino-anhydrotetracycline. This is in the S-isomer, at variance with the enzymes in the ChdN family, that appear to have the opposite stereochemistry.

The amino group donor is not specified, because a soluble version of recombinant OxyQ has not yet been obtained.

Organisms -Eubacteria


oxyq (10)
Links Enzyme (activities) oxyq
BRENDA (activities) oxyq
KEGG (pathways) oxyq
PLPMDB (PLP mutants) oxyq
 Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J (2008) Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. J Am Chem Soc. 130 6068-9.

Articles on oxyq
last changed 2019/07/29 11:44

B6db activities