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perosamine_aminotransferase |
| Description |
Perosamine aminotransferase (2.6.1.-) |
| Alternative names |
perosamine synthetase;
GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase;
RfbE;
Per |
| Catalyzed reaction |
GDP-4-keto-6-deoxy-D-mannose + L-glutamate = GDP-D-perosamine + 2-oxoglutarate. |
| Cofactor |
Pyridoxal-phosphate. |
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In bacteria, the 4-amino-6-deoxy-monosaccharide D-perosamine is used for the glycosylation of products such as antibiotics and lipopolysaccharides.
Perosamine aminotransferase occurs in a wide variety of microorganisms, including pathogens, suggesting that the enzyme performs a function crucial for the normal life cycle and/or virulence of many species. |
| PDB |
1O69; |
| Organisms |
-Bacteria |
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Family |
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| Links |
Enzyme (activities) perosamine_aminotransferase
BRENDA (activities) perosamine_aminotransferase
KEGG (pathways) perosamine_aminotransferase
PLPMDB (PLP mutants) perosamine_aminotransferase
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| References |
Zhao G, Liu J, Liu X, Chen M, Zhang H, Wang PG. (2007) Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia coli O157:H7 and synthesis of GDP-perosamine in vitro
Biochem Biophys Res Commun 363 525-30. Muller-Dieckmann, Hans-Joachim ; et al. (2003) Crystals and structures of perosamine synthase homologs United States Patent Application 20030101005 . Albermann, C.; Piepersberg, W.
(2001) Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine Glycobiology 11 655-61. Godfroid, F., Taminiau, B., Danese, I., Denoel, P., Tibor, A., Weynants, V., Cloeckaert, A., Godfroid, J.; Letesson J.J.
(1998) Identification of the perosamine synthetase gene of Brucella melitensis 16M and involvement of lipopolysaccharide O side chain in Brucella survival in mice and in macrophages Infect. Immun. 66 5485-5493. |
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| last changed |
2008/05/21 19:10 |
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