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B6db activities: pgat

Description Phenylglycine aminotransferase (2.6.1.-)
Alternative names L-phenylglycine transaminase.
PglE (gene name; ambiguous);
Catalyzed reaction phenylglyoxylate + L-tyrosine = L-phenylglycine + 4-hydroxyphenylpyruvate
Cofactor Pyridoxal-phosphate.
Comments L-Phe can also serve as the amino group donor (yielding phenylpyruvate as a product).
The enzyme from Streptomyces pristinaespiralis is involved in the biosynthesis of the antibiotic pristinamycin PI.
Organisms -Eubacteria


pgat (0)
Links Enzyme (activities) pgat
BRENDA (activities) pgat
KEGG (pathways) pgat
PLPMDB (PLP mutants) pgat
 Osipenkov N, Kulik A, Mast YJ (2018) Characterization of the phenylglycine aminotransferase PglE from Streptomyces pristinaespiralis J Biotechnol 278 34-38.

 Liu SP, Liu RX, El-Rotail AA, Ding ZY, Gu ZH, Zhang L, Shi GY (2014) Heterologous pathway for the production of L-phenylglycine from glucose by E. coli J Biotechnol 186 91-7.

 Mast YJ, Wohlleben W, Schinko E. (2011) Identification and functional characterization of phenylglycine biosynthetic genes involved in pristinamycin biosynthesis in Streptomyces pristinaespiralis J Biotechnol 155 63-7.

Articles on pgat
last changed 2018/05/14 09:45

B6db activities