B6db activities : pgle

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	pgle
Description	PglE-like aminotransferase (2.6.1.-)
Catalyzed reaction	UDP-2-acetamido-2,6-dideoxy-{alpha}-D-xylo-4-hexulose + L-glutamate = UDP-4,6-dideoxy-{alpha}-D-GlcNAc + 2-oxoglutarate.
Cofactor	Pyridoxal phosphate.
Comments	In C. jejuni PglE is involved in the general glycosylation pathway (Pgl) responsible for the N-linked modification of proteins with a heptasaccharide containing 2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose, a derivative of bacillosamine. Specifically, the product of the PglE aminotransferase is UDP-4-amino-4,6-dideoxy-alpha-D-GlcNAc (UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose) - a precursor used in the production of the Pgl glycan component
Organisms	-Bacteria
Family	pgle (3)

Links	Enzyme (activities) pgle BRENDA (activities) pgle KEGG (pathways) pgle PLPMDB (PLP mutants) pgle

References	Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM. (2006) Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways J Biol Chem. 281 723-32. Articles on pgle

last changed	2008/01/22 14:04

Family