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B6db activities: pgle

pgle
Description UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose aminotransferase (2.6.1.-)
Alternative names PglE.
Catalyzed reaction UDP-2-acetamido-2,6-dideoxy-{alpha}-D-xylo-4-hexulose + L-glutamate = UDP-4,6-dideoxy-{alpha}-D-GlcNAc + 2-oxoglutarate.
Cofactor Pyridoxal phosphate.
Comments In C. jejuni PglE is involved in the general glycosylation pathway (Pgl) responsible for the N-linked modification of proteins with a heptasaccharide containing 2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose, a derivative of bacillosamine.
Specifically, the product of the PglE aminotransferase is UDP-4-amino-4,6-dideoxy-alpha-D-GlcNAc (UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose) - a precursor used in the production of the Pgl glycan component
PDB 1O61;
Organisms -Eubacteria
 

Family 

pgle (3)
 
Links Enzyme (activities) pgle
BRENDA (activities) pgle
KEGG (pathways) pgle
PLPMDB (PLP mutants) pgle
 
References
 Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM. (2006) Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways J Biol Chem. 281 723-32.

Articles on pgle
 
last changed 2010/04/13 14:27

B6db activities