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pigh |
| Description |
4-hydroxy-2,2'-bipyrrole-5-methanol synthase (2.3.1.-) |
| Alternative names |
HBM synthase;
PigH (gene name);
RedN (gene name) |
| Catalyzed reaction |
L-serine + pyrrolyl-β-ketothioester-ACP = 4-hydroxy-2,2′-bipyrrole-5-methanol + CO(2) + ACP |
| Cofactor |
Pyridoxal phosphate |
| Comments |
The enzyme is involved in the synthesis of prodigiosin. |
| Organisms |
-Eubacteria |
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Family |
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| Links |
Enzyme (activities) pigh
BRENDA (activities) pigh
KEGG (pathways) pigh
PLPMDB (PLP mutants) pigh
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| References |
Garneau-Tsodikova S, Dorrestein PC, Kelleher NL, Walsh CT. (2006) Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. J Am Chem Soc. 128 12600-1. Williamson NR, Simonsen HT, Ahmed RA, Goldet G, Slater H, Woodley L, Leeper FJ, Salmond GP. (2005) Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces. Mol Microbiol. 56 971-89. |
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| last changed |
2019/01/14 12:26 |
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