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B6db activities: plu3042

plu3042
Description 3,4-dihydrotyrosine transaminase (2.6.1.-)
Alternative names 3,4-dihydrotyrosine aminotransferase;
Plu3042 (gene name);
Catalyzed reaction 3,4-dihydro-hydroxyphenylpyruvate+glutamine = 3,4-dihydrotyrosine +2-oxoglutaramate
Cofactor Pyridoxal-phosphate
The enzyme from Photorabdus luminescens is required for production of 2,5-Dihydrophenylalanine (H(2)Phe), together with two other enzymes encoded by the same gene cluster (plu30423044).
H(2)Phe is a multipotent nonproteinogenic amino acid, acting as an antimetabolite against many organisms.
Organisms -Eubacteria
 

Family 

plu3042 (0)
 
Links Enzyme (activities) plu3042
BRENDA (activities) plu3042
KEGG (pathways) plu3042
PLPMDB (PLP mutants) plu3042
 
References
 Crawford JM, Mahlstedt SA, Malcolmson SJ, Clardy J, Walsh CT (2011) Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis Chem Biol 18 1102-12.

Articles on plu3042
 
last changed 2018/04/03 15:10

B6db activities