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pqra |
| Description |
5-amino-4-keto 6-phenylhexanoate synthase (2.5.1.-) |
| Catalyzed reaction |
succinyl-CoA + L-phenylalanine = 5-amino-4-keto 6-phenylhexanoate + CoA + CO(2). |
| Cofactor |
Pyridoxal-phosphate. |
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An amino acid C-acyltransferase (decarboxylating).
The enzyme is involved in the biosynthesis of perquinolines A-C in Streptomyces sp. IB2014/016-6. |
| Organisms |
-Eubacteria |
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Family |
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| Links |
Enzyme (activities) pqra
BRENDA (activities) pqra
KEGG (pathways) pqra
PLPMDB (PLP mutants) pqra
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| References |
Rebets Y, Nadmid S, Paulus C, Dalem C, Hermann J, Hübner H, Rückert C, Kiemer A, Gmeiner P, Kalinowski J, Müller R, Luzhetskyy A (2019) Perquinolines A-C: Unprecedented Bacterial Tetrahydroisoquinolines Involving an Intriguing Biosynthesis
Angew Chem Int Ed Engl 58 12930-12934. |
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| last changed |
2019/08/07 17:00 |
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