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B6db activities: pqra

Description 5-amino-4-keto 6-phenylhexanoate synthase (2.5.1.-)
Catalyzed reaction succinyl-CoA + L-phenylalanine = 5-amino-4-keto 6-phenylhexanoate + CoA + CO(2).
Cofactor Pyridoxal-phosphate.
An amino acid C-acyltransferase (decarboxylating).
The enzyme is involved in the biosynthesis of perquinolines A-C in Streptomyces sp. IB2014/016-6.
Organisms -Eubacteria


pqra (0)
Links Enzyme (activities) pqra
BRENDA (activities) pqra
KEGG (pathways) pqra
PLPMDB (PLP mutants) pqra
 Rebets Y, Nadmid S, Paulus C, Dalem C, Hermann J, Hübner H, Rückert C, Kiemer A, Gmeiner P, Kalinowski J, Müller R, Luzhetskyy A (2019) Perquinolines A-C: Unprecedented Bacterial Tetrahydroisoquinolines Involving an Intriguing Biosynthesis Angew Chem Int Ed Engl 58 12930-12934.

Articles on pqra
last changed 2019/08/07 17:00

B6db activities