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B6db activities: qbsb

Description 3-hydroxykynurenine aminotransferase (2.6.1.-)
Catalyzed reaction 3-hydroxy-L-kynurenine + 2-oxoglutarate = 4,8-dihydroxyquinoline-2-carboxylate + L-glutamate
Cofactor Pyridoxal phosphate
3-hydroxykynurenine (α,2-diamino-3-hydroxy-γ-oxo-Benzenebutanoic acid) is not to be confused with beta-hydroxykynurenine, substrate of the enzyme swb1.

The enzyme from Pseudomonas is involved in the biosynthesis siderophore quinolobactin.
The immediate keto product of the reaction, 4-(2-amino 3-hydroxyphenyl)-2,4-dioxobutanoate, is converted into 4,8-dihydroxyquinoline-2-carboxylate (3-hydroxykynurenate) by a spontaneous reaction.

Organisms -Eubacteria


qbsb (0)
Links Enzyme (activities) qbsb
BRENDA (activities) qbsb
KEGG (pathways) qbsb
PLPMDB (PLP mutants) qbsb
 Godert A.M. (2006) Investigatin the biosynthesis of thio-quinolobactin and the development of a proteomics probe for thiamin utilinzing enzymes PhD thesis, Cornell University 1-202.

 Matthijs S, Baysse C, Koedam N, Tehrani KA, Verheyden L, Budzikiewicz H, Schäfer M, Hoorelbeke B, Meyer JM, De Greve H, Cornelis P (2004) The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway Mol Microbiol 52 371-84.

Articles on qbsb
last changed 2019/06/20 13:12

B6db activities