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B6db activities: rubn4

rubn4
Description TDP-3,4-didehydro-2,6-dideoxy-D-glucose aminotransferase (2.6.1.-)
Alternative names rubN4.
Catalyzed reaction TDP-3,4-didehydro-2,6-dideoxy-D-glucose + L-glutamine = TDP-3-amino-4-dehydro-2,3,6-trideoxy-D-glucose + 2-oxoglutaramate.
Cofactor Pyridoxal phosphate.
In Streptomyces achromogenes, the activity is required for the biosynthetic pathway leading to the production of the antibiotic rubradirin.
Organisms -Eubacteria
 

Family 

rubn4 (14)
 
Links Enzyme (activities) rubn4
BRENDA (activities) rubn4
KEGG (pathways) rubn4
PLPMDB (PLP mutants) rubn4
 
References
 Lamichhane J, Liou K, Lee HC, Kim CG, Sohng JK. (2006) Functional characterization of ketoreductase (rubN6) and aminotransferase (rubN4) genes in the gene cluster of Streptomyces achromogenes var. rubradiris Biotechnol Lett 28 545-53.

 Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD. (2000) Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis Proc Natl Acad Sci U S A 97 11942-7.

Articles on rubn4
 
last changed 2009/07/23 13:17

B6db activities