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B6db activities: swb1

Description Beta-hydroxykynurenine aminotransferase (2.6.1.-)
Catalyzed reaction Beta-hydroxy-L-kynurenine + 2-oxoglutarate = 3,4-dihydroxyquinoline-2-carboxylate + L-glutamate
Cofactor Pyridoxal phosphate
The enzyme is not to be confused with 3-hydroxykynurenine aminotransferase (QbsB).

The immediate keto product of the reaction, 4-(2-amino phenyl)-3-hydroxy 2,4-dioxobutanoate, is converted into 3,4-dihydroxyquinoline-2-carboxylate by a spontaneous reaction.

Organisms -Eubacteria


swb1 (0)
Links Enzyme (activities) swb1
BRENDA (activities) swb1
KEGG (pathways) swb1
PLPMDB (PLP mutants) swb1
 Hirose Y, Watanabe K, Minami A, Nakamura T, Oguri H, Oikawa H. (2011) Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics. J Antibiot (Tokyo) 64 117-122.

Articles on swb1
last changed 2019/06/20 13:19

B6db activities