|
|
tatt |
Description |
Branched chain/aromatic amino acid transaminase (2.6.1.-) |
Catalyzed reaction |
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate. |
Cofactor |
Pyridoxal-phosphate |
|
The enzyme from Thermobaculum terrenum was found to be highly active toward branched-chain amino acids (BCAAs), as well as toward phenylalanine and other ariomatic amino acids. The preferred amino group acceptor was 2-ketoglutarate (and the ketoacids corresponding to some branched-chains and aromatic amino acids). Pyruvate was a poor acceptor, in contrast to the archaeal enzymes of the tuzn1299 family (which are the closest homologs to this group of transaminases). Sequences are relatively distinct from those of classic BCAATs (family 2.6.1.42a) |
PDB |
6GKR; |
Organisms |
-Eubacteria |
| |
Family |
|
| |
Links |
Enzyme (activities) tatt
BRENDA (activities) tatt
KEGG (pathways) tatt
PLPMDB (PLP mutants) tatt
|
| |
References |
Articles on tatt |
| |
last changed |
2019/06/20 13:20 |
|