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B6db activities: tatt

Description Branched chain/aromatic amino acid transaminase (2.6.1.-)
Catalyzed reaction L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate.
Cofactor Pyridoxal-phosphate
The enzyme from Thermobaculum terrenum was found to be highly active toward branched-chain amino acids (BCAAs), as well as toward phenylalanine and other ariomatic amino acids. The preferred amino group acceptor was 2-ketoglutarate (and the ketoacids corresponding to some branched-chains and aromatic amino acids). Pyruvate was a poor acceptor, in contrast to the archaeal enzymes of the tuzn1299 family (which are the closest homologs to this group of transaminases). Sequences are relatively distinct from those of classic BCAATs (family
Organisms -Eubacteria


tatt (0)
Links Enzyme (activities) tatt
BRENDA (activities) tatt
KEGG (pathways) tatt
PLPMDB (PLP mutants) tatt
 Bezsudnova EY, Boyko KM, Nikolaeva AY, Zeifman YS, Rakitina TV, Suplatov DA, Popov VO (2019) Biochemical and structural insights into PLP fold type IV transaminase from Thermobaculum terrenum Biochimie 158 130-138.

Articles on tatt
last changed 2019/06/20 13:20

B6db activities