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B6db activities: unclassified

unclassified
Description unclassified activities
Cofactor Pyridoxal phosphate.
Comments In this entry, we include proteins whose three-dimensional structure has been solved and (preferably) that have been described in the literature but, despite being certainly PLP-dependent, do not have any recognized biochemical or physiological function.
Diseases Pyridoxine-responsive seizures (prosc).
PDB 1B54; 1IUG; 1J0A;
 

Family 

 
Links Enzyme (activities) unclassified
BRENDA (activities) unclassified
KEGG (pathways) unclassified
PLPMDB (PLP mutants) unclassified
 
References
 Darin N, Reid E, Prunetti L, Samuelsson L, Husain RA, Wilson M, El Yacoubi B, Footitt E, Chong WK, Wilson LC, Prunty H, Pope S, Heales S, Lascelles K, Champion M, Wassmer E, Veggiotti P, de Crécy-Lagard V, Mills PB, Clayton PT (2016) Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy Am J Hum Genet 99 1325-1337.

 Prunetti L, El Yacoubi B, Schiavon CR, Kirkpatrick E, Huang L, Bailly M, ElBadawi-Sidhu M, Harrison K, Gregory JF, Fiehn O, Hanson AD, de Crécy-Lagard V (2016) Evidence That COG0325 Proteins are involved in PLP Homeostasis Microbiology 195 694-706.

 Ito T1, Iimori J, Takayama S, Moriyama A, Yamauchi A, Hemmi H, Yoshimura T. (2013) Conserved pyridoxal protein that regulates Ile and Val metabolism J Bacteriol. 195 5439-49.

 Fujino A, Ose T, Yao M, Tokiwano T, Honma M, Watanabe N, Tanaka I. (2004) Structural and enzymatic properties of 1-aminocyclopropane-1-carboxylate deaminase homologue from Pyrococcus horikoshii. J Mol Biol. 341 999-1013.

 Eswaramoorthy, S.; Gerchman, S,; Graziano, V.; Kycia, H.; Studier, F.W.; Swaminathan, S. (2003) Structure of a yeast hypothetical protein selected by a structural genomics approach. Acta Crystallogr D Biol Crystallogr. 59 127-135.

 Ikegawa S.; Isomura M.; Koshizuka Y.; Nakamura Y. (1999) Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes J Hum Genet. 44 337-342.

Articles on unclassified
 
last changed 2018/02/07 13:12

B6db activities