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B6db activities: vzb9

Description 2-amino-5,7-dihydroxy-6-keto-heptanoic-[Vzb22 amino carrier protein] transaminase (2.6.1.-)
Alternative names Vzb9 (gene name)
Catalyzed reaction 2-amino-5,7-dihydroxy-6-keto-heptanoic-[Vzb22 amino carrier protein] + L-glutamate = 2,6-diamino-5,7-dihydroxy-heptanoic acid-[Vzb22 amino carrier protein] + 2-oxoglutarate.
Cofactor Pyridoxal-phosphate
Comments The enzyme from Streptomyces sp. SANK 60404 is involved in the biosynthetic pathway of vazabitide A. Vazabitide A derives from the nonproteinogenic amino acid (2S,6R)-diamino-(5R,7)-dihydroxy-heptanoic acid (DADH). The product of Vzb9, DADH-[Vzb22 amino carrier protein], follows hydrolysis by Vzb26 to release DADH.

The activity is similar to L-glutamine:2-deoxy-scyllo-inosose aminotransferase (

Organisms -Eubacteria


vzb9 (0)
Links Enzyme (activities) vzb9
BRENDA (activities) vzb9
KEGG (pathways) vzb9
PLPMDB (PLP mutants) vzb9
 Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama M. (2016) Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces Nat Chem Biol. 12 967-972.

Articles on vzb9
last changed 2019/06/20 13:21

B6db activities