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vzb9 |
Description |
2-amino-5,7-dihydroxy-6-keto-heptanoic-[Vzb22 amino carrier protein] transaminase (2.6.1.-) |
Alternative names |
Vzb9 (gene name) |
Catalyzed reaction |
2-amino-5,7-dihydroxy-6-keto-heptanoic-[Vzb22 amino carrier protein] + L-glutamate = 2,6-diamino-5,7-dihydroxy-heptanoic acid-[Vzb22 amino carrier protein] + 2-oxoglutarate. |
Cofactor |
Pyridoxal-phosphate |
Comments |
The enzyme from Streptomyces sp. SANK 60404 is involved in the biosynthetic pathway of vazabitide A.
Vazabitide A derives from the nonproteinogenic amino acid (2S,6R)-diamino-(5R,7)-dihydroxy-heptanoic acid (DADH). The product of Vzb9, DADH-[Vzb22 amino carrier protein], follows hydrolysis by Vzb26 to release DADH.
The activity is similar to L-glutamine:2-deoxy-scyllo-inosose aminotransferase (2.6.1.100) |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) vzb9
BRENDA (activities) vzb9
KEGG (pathways) vzb9
PLPMDB (PLP mutants) vzb9
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References |
Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama M. (2016) Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces Nat Chem Biol. 12 967-972. Articles on vzb9 |
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last changed |
2019/06/20 13:21 |
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