|
type |
Journal Article |
authors |
Li, G.; Foote, C.; Alexander, S.; Alexander, H. |
title |
Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum |
journal |
Development |
Activity |
4.1.2.27 |
Family |
4.1.2.27 |
sel |
selected |
ui |
11566853 |
year |
(2001) |
volume |
128 |
number |
18 |
pages |
3473-83 |
| |
keywords |
Aldehyde-Lyases/genetics/*physiology |
abstract |
Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element of signal transduction pathways that regulate cell proliferation and cell death. We have demonstrated additional roles for sphingosine-1-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme that catalyzes sphingosine-1-phosphate degradation, results in a mutant strain with aberrant morphogenesis, as well as an increase in viability during stationary phase. The absence of sphingosine-1-phosphate lyase affects multiple stages throughout development, including the cytoskeletal architecture of aggregating cells, the ability to form migrating slugs, and the control of cell type-specific gene expression and terminal spore differentiation. This pleiotropic effect, which is due to the loss of sphingosine-1-phosphate lyase, establishes sphingolipids as pivotal regulatory molecules in a wide range of processes in multicellular development. |
last changed |
2009/06/23 09:14 |
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