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B6db references: 15612036

type Journal Article
authors Moya-Garcia AA, Medina MA, Sánchez-Jiménez F.
title Mammalian histidine decarboxylase: from structure to function
journal Bioessays
sel selected
ui 15612036
year (2005)
volume 27
number 1
pages 57-63
keywords Animal
abstract Histamine is a multifunctional biogenic amine with relevant roles in intercellular communication, inflammatory processes and highly prevalent pathologies. Histamine biosynthesis depends on a single decarboxylation step, carried out by a PLP-dependent histidine decarboxylase activity (EC, an enzyme that still remains to be fully characterized. Nevertheless, during the last few years, important advances have been made in this field, including the generation and validation of the first three-dimensional model of the enzyme, which allows us to revisit previous results and conclusions. This essay provides a comprehensive review of the current knowledge of the structural and functional characteristics of mammalian histidine decarboxylase.
last changed 2008/01/24 14:40

B6db references