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B6db references: 15737611.

type Journal Article
authors Ikeda M, Kihara A, Kariya Y, Lee YM, Igarashi Y.

title Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme
journal Biochem Biophys Res Commun
sel selected
ui 15737611
year (2005)
volume 329
number 2
pages 474-9
abstract Sphingosine-1-phosphate (S1P) lyase catalyzes the cleavage of the bioactive lipid molecule S1P to phosphoethanolamine and hexadecenal, both of which are utilized as glycerophospholipid precursors. Until now, only one gene, SPL, has been identified as encoding a S1P lyase. In the present study, SPL-null F9 cells were able to convert radiolabeled dihydrosphingosine to glycerophospholipids, albeit at much lower efficiency than parent cells. Lysates prepared from the SPL-null cells exhibited weak but significant dihydrosphingosine-1-phosphate lyase activity in vitro. These results provide evidence of the existence of an alternative S1P lyase.
last changed 2008/02/15 13:44

B6db references