|
type |
Journal Article |
authors |
Kim PM, Duan X, Huang AS, Liu CY, Ming GL, Song H, Snyder SH |
title |
Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis |
journal |
Proc Natl Acad Sci U S A |
Activity |
5.1.1.13 |
sel |
selected |
ui |
20133766 |
year |
(2010) |
volume |
107 |
number |
7 |
pages |
3175-9 |
| |
abstract |
D-aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development and survival of newborn neurons and survival. Because D-aspartate is a potential endogenous ligand for NMDA receptors, the loss of which elicits a phenotype resembling DR depletion, D-aspartate may function as a modulator of adult neurogenesis. |
last changed |
2019/03/29 12:57 |
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