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B6db references: 20243507

type Journal Article
authors Adcock, H. J.; Brophy, P. M.; Teesdale-Spittle, P. H.; Buckberry, L. D.
title Purification and characterisation of a novel cysteine conjugate beta- lyase from the tapeworm Moniezia expansa
journal Int J Parasitol
ui 20243507
year (2000)
volume 30
number 5
pages 567-71.
keywords Animal
abstract The paper presents the first report of the purification of an invertebrate cysteine conjugate beta-lyase (CCBL). CCBL activity was shown to predominate within the cytosolic fraction of tissue from the tapeworm Moniezia expansa. The monomeric cytosolic enzyme was isolated with a M(r) of 72 kDa and co-purified with transaminase activity towards L-aspartate. The substrate profile for M. expansa CCBL is different from that of mammalian CCBLs. Exploiting the differences in mammalian and parasite substrate profiles will facilitate the development of helminth targeted conjugates which will not be activated by host (mammalian) CCBLs.
last changed 2002/11/12 16:17

B6db references