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B6db references: 21861518

type Journal Article
authors Ragab AE, Grüschow S, Tromans DR, Goss RJ
title Biogenesis of the unique 4',5'-dehydronucleoside of the uridyl peptide antibiotic pacidamycin
journal J Am Chem Soc.
Activity lipo
Family lipo
sel selected
ui 21861518
year (2011)
volume 133
number 39
pages 15288-91
keywords doi: 10.1021/ja206163j
abstract The pacidamycins belong to a class of antimicrobial nucleoside antibiotics that act by inhibiting the clinically unexploited target translocase I, a key enzyme in peptidoglycan assembly. As with other nucleoside antibiotics, the pacidamycin 4',5'-dehydronucleoside portion is an essential pharmacophore. Here we show that the biosynthesis of the pacidamycin nucleoside in Streptomyces coeruleorubidus proceeds through three steps from uridine. The transformations involve oxidation of the 5'-alcohol by Pac11, transamination of the resulting aldehyde by Pac5, and dehydration by the Cupin-domain protein Pac13.
last changed 2018/04/03 17:45

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