|
type |
Journal Article |
authors |
Shinohara Y, Kudo F, Eguchi T. |
title |
A natural protecting group strategy to carry an amino acid starter unit in the biosynthesis of macrolactam polyketide antibiotics |
journal |
J Am Chem Soc. |
Activity |
vino |
Family |
vino |
sel |
selected |
ui |
22010945 |
year |
(2011) |
volume |
133 |
number |
45 |
pages |
18134-7 |
| |
keywords |
doi: 10.1021/ja208927r |
abstract |
Macrolactam antibiotics are an important class of macrocyclic polyketides that contain a unique nitrogen-containing starter unit. In the present study, a set of starter biosynthetic enzymes in the macrolactam antibiotic vicenistatin was characterized. We found that the protection-deprotection strategy of the aminoacyl-ACP intermediate was critical in this system. On the basis of bioinformatics, the described pathway is also proposed as a common method for carrying amino acids in the biosynthesis of other macrolactam antibiotics. |
last changed |
2018/11/14 08:49 |
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