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B6db references: 2590185

type Journal Article
authors Ichinose, H.; Kurosawa, Y.; Titani, K.; Fujita, K.; Nagatsu, T.
title Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase
journal Biochem Biophys Res Commun
sel selected
ui 2590185
year (1989)
volume 164
number 3
pages 1024-30
keywords Adrenal Gland Neoplasms/*enzymology/genetics
abstract The nucleotide sequence of a cDNA clone that includes the entire coding region of human aromatic L-amino acid decarboxylase gene is presented. A human pheochromocytoma cDNA library was screened using an oligonucleotide probe which corresponded to a partial amino acid sequence of the enzyme purified from the human pheochromocytoma. The isolated cDNA clone encoded a protein of 480 amino acids with a calculated molecular mass of 53.9 kDa. The amino acid sequence Asn-Phe- Asn-Pro-His-Lys-Trp around a possible cofactor (pyridoxal phosphate) binding site is identical in human, Drosophila, and pig enzymes.
last changed 2009/06/12 11:42

B6db references