|
type |
Journal Article |
authors |
Ichinose, H.; Kurosawa, Y.; Titani, K.; Fujita, K.; Nagatsu, T. |
title |
Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase |
journal |
Biochem Biophys Res Commun |
Activity |
4.1.1.28 |
Family |
4.1.1.28 |
sel |
selected |
ui |
2590185 |
year |
(1989) |
volume |
164 |
number |
3 |
pages |
1024-30 |
| |
keywords |
Adrenal Gland Neoplasms/*enzymology/genetics |
abstract |
The nucleotide sequence of a cDNA clone that includes the entire coding region of human aromatic L-amino acid decarboxylase gene is presented. A human pheochromocytoma cDNA library was screened using an oligonucleotide probe which corresponded to a partial amino acid sequence of the enzyme purified from the human pheochromocytoma. The isolated cDNA clone encoded a protein of 480 amino acids with a calculated molecular mass of 53.9 kDa. The amino acid sequence Asn-Phe- Asn-Pro-His-Lys-Trp around a possible cofactor (pyridoxal phosphate) binding site is identical in human, Drosophila, and pig enzymes. |
last changed |
2009/06/12 11:42 |
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