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B6db references: 27116378

type Journal Article
authors Machingura M, Salomon E, Jez JM, Ebbs SD
title The β-cyanoalanine synthase pathway: beyond cyanide detoxification
journal Plant Cell Environ
sel selected
ui 27116378
year (2016)
volume 39
number 10
pages 2329-41
keywords cyanide; cyanide detoxification; nitrilase; nitrile hydratase; β-cyanoalanine; β-cyanoalanine synthase
abstract Production of cyanide through biological and environmental processes requires the detoxification of this metabolic poison. In the 1960s, discovery of the β-cyanoalanine synthase (β-CAS) pathway in cyanogenic plants provided the first insight on cyanide detoxification in nature. Fifty years of investigations firmly established the protective role of the β-CAS pathway in cyanogenic plants and its role in the removal of cyanide produced from ethylene synthesis in plants, but also revealed the importance of this pathway for plant growth and development and the integration of nitrogen and sulfur metabolism. This review describes the β-CAS pathway, its distribution across and within higher plants, and the diverse biological functions of the pathway in cyanide assimilation, plant growth and development, stress tolerance, regulation of cyanide and sulfide signalling, and nitrogen and sulfur metabolism. The collective roles of the β-CAS pathway highlight its potential evolutionary and ecological importance in plants.
last changed 2017/09/14 09:19

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