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B6db references: 27166860

type Journal Article
authors Ye Y, Minami A, Igarashi Y, Izumikawa M, Umemura M, Nagano N, Machida M, Kawahara T, Shin-Ya K, Gomi K, Oikawa H.
title Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post‐translationally Modified Peptide Ustiloxin B in Filamentous Fungi
journal Angew Chem Int Ed Engl
Activity ustd
Family ustd
PLP Fold Type 1
sel selected
ui 27166860
year (2016)
volume 55
number 28
pages 8072-5
abstract The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results confirmed an essential requirement for novel oxidases possessing the DUF3328 motif for macrocyclization, and highly unique side-chain modifications by three oxidases (UstCF1F2) and a pyridoxal 5'-phosphate (PLP)-dependent enzyme (UstD). These findings provide new insight into the expression of the RiPP gene clusters found in various fungi.
last changed 2018/11/20 12:59

B6db references