|
type |
Journal Article |
authors |
Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama M. |
title |
Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces |
journal |
Nat Chem Biol. |
Activity |
vzb9 |
Family |
vzb9 |
PLP Fold Type |
1 |
sel |
selected |
ui |
28288097 |
year |
(2016) |
volume |
12 |
number |
11 |
pages |
967-972 |
| |
keywords |
DOI: 10.1038/nchembio.2181 |
abstract |
Amino-group carrier proteins (AmCPs) mediate the biosynthesis of lysine and arginine in some bacteria and archaea. Here we demonstrate that an uncharacterized AmCP-mediated biosynthetic system functions to biosynthesize the previously uncharacterized and nonproteinogenic amino acid (2S,6R)-diamino-(5R,7)-dihydroxy-heptanoic acid (DADH) in Streptomyces sp. SANK 60404. DADH is incorporated into a novel peptide metabolite, vazabitide A, featuring an azabicyclo-ring structure, by nonribosomal peptide synthetases and successive modification enzymes in this bacterium. As the AmCP-mediated machinery for DADH biosynthesis is widely distributed in bacteria, further analysis of uncharacterized AmCP-containing gene clusters will lead to the discovery of novel bioactive compounds and novel biosynthetic enzymes. |
last changed |
2018/11/27 16:42 |
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