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B6db references: 76116118

type Journal Article
authors Meadows, G. G.; DiGiovanni, J.; Minor, L.; Elmer, G. W.
title Some biological properties and an in vivo evaluation of tyrosine phenol- lyase on growth of B-16 melanoma
journal Cancer Res
ui 76116118
year (1976)
volume 36
number 1
pages 167-71.
keywords Animal
abstract Tyrosine phenol-lyase from Erwinia herbicola was purified with the goal of assessing its effect on growth of malignant melanoma. Ammonium sulfate-sodium citrate fractionation and diethylaminoethyl cellulose- hydroxylapatite chromatography were used. The purified enzyme was shown to reduce plasma tyrosine levels when administered to normal C57BL x DBA/2 F1 mice. The plasma half-life value of the enzyme was found to be 6 to 7 hr. Unlike results reported with glutaminase and asparaginase preparations, the lactate dehydrogenase-elevating virus had no significant influence on plasma clearance of tyrosine phenol-lyase. The enzyme significantly inhibited growth of established B-16 melanoma tumors.
last changed 2002/11/12 16:17

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