Activities | Families | Sequences | Fold types | References | Help
B6db references: 82007502

type Journal Article
authors Kern, B. A.; Inamine, E.
title Cystathionine gamma-lyase activity in the cephamycin C producer Streptomyces lactamdurans
journal J Antibiot (Tokyo)
ui 82007502
year (1981)
volume 34
number 5
pages 583-9.
keywords Antibiotics/*biosynthesis
abstract Extracts of the cephamycin C producer S. lactamdurans were found to possess cystathionine gamma-lyase activity (E.C. This represents the first demonstration of this enzyme of the reverse transsulfuration pathway in a prokaryotic organism. A likely involvement of reverse transsulfuration in antibiotic synthesis is indicated by the fact that propargylglycine, a mechanism-based inhibitor of the gamma-lyase, is a strong inhibitor of cephamycin C production.
last changed 2008/04/02 19:23

B6db references