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B6db references: 82007502

type Journal Article
authors Kern, B. A.; Inamine, E.
title Cystathionine gamma-lyase activity in the cephamycin C producer Streptomyces lactamdurans
journal J Antibiot (Tokyo)
Activity 4.4.1.1
Family 4.4.1.1
ui 82007502
year (1981)
volume 34
number 5
pages 583-9.
 
keywords Antibiotics/*biosynthesis
abstract Extracts of the cephamycin C producer S. lactamdurans were found to possess cystathionine gamma-lyase activity (E.C. 4.4.1.1). This represents the first demonstration of this enzyme of the reverse transsulfuration pathway in a prokaryotic organism. A likely involvement of reverse transsulfuration in antibiotic synthesis is indicated by the fact that propargylglycine, a mechanism-based inhibitor of the gamma-lyase, is a strong inhibitor of cephamycin C production.
last changed 2008/04/02 19:23

B6db references