|
type |
Journal Article |
authors |
Kern, B. A.; Inamine, E. |
title |
Cystathionine gamma-lyase activity in the cephamycin C producer Streptomyces lactamdurans |
journal |
J Antibiot (Tokyo) |
Activity |
4.4.1.1 |
Family |
4.4.1.1 |
ui |
82007502 |
year |
(1981) |
volume |
34 |
number |
5 |
pages |
583-9. |
| |
keywords |
Antibiotics/*biosynthesis |
abstract |
Extracts of the cephamycin C producer S. lactamdurans were found to possess cystathionine gamma-lyase activity (E.C. 4.4.1.1). This represents the first demonstration of this enzyme of the reverse transsulfuration pathway in a prokaryotic organism. A likely involvement of reverse transsulfuration in antibiotic synthesis is indicated by the fact that propargylglycine, a mechanism-based inhibitor of the gamma-lyase, is a strong inhibitor of cephamycin C production. |
last changed |
2008/04/02 19:23 |
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