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B6db references: 83055302

type Journal Article
authors Huber, B. E.; Brown, N. A.
title Developmental patterns of ornithine decarboxylase activity in organogenesis phase rat embryos in culture and in utero
journal In Vitro
ui 83055302
year (1982)
volume 18
number 7
pages 599-605.
keywords Animal
abstract Ornithine decarboxylase activity was measured during organogenesis in rat embryos grown in utero and whole rat conceptuses maintained in an in vitro culture system. Ornithine decarboxylase levels in vivo showed a distinct peak at embryonic age 10.5 d. Despite identical morphology, protein content, crown rump length and numbers of somites cultured embryos displayed a different developmental pattern and possessed less than half the ODC activity of that in vivo. The data suggest that the normal embryonic programming of ODC activity is significantly altered by the culture environment and that further biochemical comparisons of embryos growing in utero and in vitro may be required to evaluate properly the applicability of this technique to detailed studies of teratogenesis and developmental biology.
last changed 2002/11/12 16:17

B6db references