|
type |
Journal Article |
authors |
Simon, M.; Hong, J. S. |
title |
Direct homocysteine biosynthesis from O-succinylhomoserine in Escherichia coli: an alternate pathway that bypasses cystathionine |
journal |
J Bacteriol |
Activity |
2.5.1.49 |
ui |
83082661 |
year |
(1983) |
volume |
153 |
number |
1 |
pages |
558-61. |
| |
keywords |
Cystathionine/metabolism |
abstract |
Mutations were found which enable Escherichia coli K-12 to form homocysteine in the absence of cystathionase. The formation of homocysteine in the mutant strains required cystathionine gamma- synthetase, the metB gene product, but bypassed the normal intermediate cystathionine. It is concluded that cystathionine gamma-synthetase catalyzes the formation of homocysteine directly from O- succinylhomoserine and an as-yet-unidentified sulfur donor. The mutation apparently causes the formation of this sulfur donor and has been named metQ. The expression of the metQ gene is under catabolite repression. |
last changed |
2003/03/17 15:14 |
|