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B6db references: 83082661

type Journal Article
authors Simon, M.; Hong, J. S.
title Direct homocysteine biosynthesis from O-succinylhomoserine in Escherichia coli: an alternate pathway that bypasses cystathionine
journal J Bacteriol
ui 83082661
year (1983)
volume 153
number 1
pages 558-61.
keywords Cystathionine/metabolism
abstract Mutations were found which enable Escherichia coli K-12 to form homocysteine in the absence of cystathionase. The formation of homocysteine in the mutant strains required cystathionine gamma- synthetase, the metB gene product, but bypassed the normal intermediate cystathionine. It is concluded that cystathionine gamma-synthetase catalyzes the formation of homocysteine directly from O- succinylhomoserine and an as-yet-unidentified sulfur donor. The mutation apparently causes the formation of this sulfur donor and has been named metQ. The expression of the metQ gene is under catabolite repression.
last changed 2003/03/17 15:14

B6db references