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B6db references: 84079896

type Journal Article
authors Barra, D.; Martini, F.; Angelaccio, S.; Bossa, F.; Gavilanes, F.; Peterson, D.; Bullis, B.; Schirch, L.
title Sequence homology between prokaryotic and eukaryotic forms of serine hydroxymethyltransferase
journal Biochem Biophys Res Commun
ui 84079896
year (1983)
volume 116
number 3
pages 1007-12.
keywords Amino Acid Sequence
abstract The sequence of tryptic and chymotryptic peptides from cytosolic and mitochondrial rabbit liver serine hydroxymethyltransferase are compared to the proposed sequence of a protein coded for by the glyA gene of Escherichia coli. The E. coli glyA gene is believed to code for serine hydroxymethyltransferase. Extensive sequence homology between these peptides were found for the proposed E. coli enzyme in the aminoterminal two-thirds of the molecule. All three proteins have identical sequences from residue 222-231. This sequence is known to contain the lysyl residue which forms a Schiff's base with pyridoxal-P in the two rabbit liver enzymes. These results support the interpretation that the proposed sequence of E. coli serine hydroxymethyltransferase is correct. The data also show that cytosolic and mitochondrial serine hydroxymethyltransferase are homologous proteins.
last changed 2002/11/04 17:41

B6db references