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B6db references: 84212221

type Journal Article
authors Whalen, W. A.; Berg, C. M.
title Gratuitous repression of avtA in Escherichia coli and Salmonella typhimurium
journal J Bacteriol
ui 84212221
year (1984)
volume 158
number 2
pages 571-4.
keywords Alanine/pharmacology
abstract avtA , which encodes transaminase C (alanine-valine transaminase), is repressed by excess-L-alanine or L-leucine, and also by limitation for any of a number of amino acids in Escherichia coli and Salmonella typhimurium. Amino acid limitation causes repression by promoting the accumulation of L-alanine or L-leucine or both. avtA is also repressed by L-alpha-aminobutyric acid and other nonprotein amino acids which are structurally similar to L-alanine. We hypothesize that L-alanine and L- alpha-aminobutyric acid, whose syntheses are catalyzed by transaminase C, are the true corepressors of avtA . Repression by structural analogs of the true corepressors is termed gratuitous repression.
last changed 2002/11/02 00:35

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