|
type |
Journal Article |
authors |
Whalen, W. A.; Berg, C. M. |
title |
Gratuitous repression of avtA in Escherichia coli and Salmonella typhimurium |
journal |
J Bacteriol |
Activity |
2.6.1.66 |
ui |
84212221 |
year |
(1984) |
volume |
158 |
number |
2 |
pages |
571-4. |
| |
keywords |
Alanine/pharmacology |
abstract |
avtA , which encodes transaminase C (alanine-valine transaminase), is repressed by excess-L-alanine or L-leucine, and also by limitation for any of a number of amino acids in Escherichia coli and Salmonella typhimurium. Amino acid limitation causes repression by promoting the accumulation of L-alanine or L-leucine or both. avtA is also repressed by L-alpha-aminobutyric acid and other nonprotein amino acids which are structurally similar to L-alanine. We hypothesize that L-alanine and L- alpha-aminobutyric acid, whose syntheses are catalyzed by transaminase C, are the true corepressors of avtA . Repression by structural analogs of the true corepressors is termed gratuitous repression. |
last changed |
2002/11/02 00:35 |
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