type	Journal Article
authors	Martel, A.; Bouthier de la Tour, C.; Le Goffic, F.
title	Pyridoxal 5'phosphate binding site of Escherichia coli beta cystathionase and cystathionine gamma synthase comparison of their sequences
journal	Biochem Biophys Res Commun
Activity	2.5.1.48
ui	87326410
year	(1987)
volume	147
number	2
pages	565-71.
keywords	Amino Acid Sequence
abstract	The phosphopyridoxyl peptides of beta cystathionase and cystathionine gamma synthase of Escherichia Coli were identified after reduction, carboxymethylation and proteolysis of the holoenzymes. Their comparison with those obtained from rat liver gamma cystathionase (Fearon, C.W., Rodkey, J.A. and Abeles R.H. 1982. Biochemistry 21 3790-3794.) showed a high degree of homology between the three PLP binding sites with the presence of the tripeptide sequence: Thr-Lys(Pxy)-Tyr in their structure. This homology suggests that these enzymes of methionine metabolism have probably the same origin.
last changed	2003/03/17 15:02