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B6db references: 88216181

type Journal Article
authors Follettie, M. T.; Shin, H. K.; Sinskey, A. J.
title Organization and regulation of the Corynebacterium glutamicum hom-thrB and thrC loci
journal Mol Microbiol
ui 88216181
year (1988)
volume 2
number 1
pages 53-62.
keywords Alcohol Oxidoreductases/*genetics
abstract The genes encoding the three terminal enzymes in the threonine biosynthetic pathway, homoserine dehydrogenase (hom), homoserine kinase (thrB) and threonine synthase (thrC) have been isolated from Corynebacterium glutamicum. The C. glutamicum hom and thrB genes were subcloned on a 3.6 kb SalI-generated chromosomal fragment. The C. glutamicum thrC gene was shown not to be linked to the hom-thrB locus. L-methionine represses the cloned homoserine dehydrogenase and homoserine kinase similar to that of the chromosomally encoded hom and thrB gene products. Northern hybridization analysis demonstrates that this repression is mediated at the level of transcription and that hom- thrB represents an operon in C. glutamicum.
last changed 2002/11/12 16:17

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