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B6db references: 89365154

type Journal Article
authors Barford, D.; Johnson, L. N.
title The allosteric transition of glycogen phosphorylase
journal Nature
ui 89365154
year (1989)
volume 340
number 6235
pages 609-16.
keywords *Allosteric Regulation
abstract The crystal structure of R-state glycogen phosphorylase b has been determined at 2.9 A resolution. A comparison of T-state and R-state structures of the enzyme explains its cooperative behaviour on ligand binding and the allosteric regulation of its activity. Communication between catalytic sites of the dimer is provided by a change in packing geometry of two helices linking each site with the subunit interface. Activation by AMP or by phosphorylation results in a quaternary conformational change that switches these two helices into the R-state conformation.
last changed 2002/11/12 16:17

B6db references