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B6db references: 91092395

type Journal Article
authors Kaneko, M.; Fujimoto, S.; Kikugawa, M.; Tamaki, N.
title Irreversible inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by gabaculine
journal FEBS Lett
ui 91092395
year (1990)
volume 276
number 1-2
pages 115-8.
keywords 4-Aminobutyrate Transaminase/antagonists & inhibitors
abstract Gabaculine, 5-amino-1,3-cyclohexadienylcarboxylate, is an analogue of GABA and a potent irreversible inhibitor of GABA aminotransferase. However, D-3-aminoisobutyrate-pyruvate aminotransferase for which GABA was neither a substrate nor an inhibitor was also inactivated by gabaculine. The Ki for D-3-aminoisobutyrate-pyruvate aminotransferase was 8.3 x 10(-6) M, and the Kcat for its turnover was 0.31 min-1 at 25 degrees C. beta-Alanine protected the enzyme from inactivation by gabaculine, but GABA did so to much a lesser extent.
last changed 2002/11/12 16:17

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