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B6db references: 91210892

type Journal Article
authors Steven, F. S.; Williams, L. A.; Warne, P.; Tucker, D. F.
title Fluorescent location of ornithine decarboxylase employing derivatives of the specific inhibitor alpha-difluoromethyl ornithine
journal J Enzyme Inhib
ui 91210892
year (1989)
volume 3
number 2
pages 133-43
keywords Animal
abstract Two fluorescent derivatives have been made from alpha-difluoromethyl ornithine by linking the carboxyl group of the ornithine derivatives to fluorescent amines. alpha-difluoromethyl ornithine is a potent inhibitor of ornithine decarboxylase, an enzyme which plays an essential role in cell division. We have used these fluorescent derivatives as probes for ornithine decarboxylase in frozen sections of skin to locate the epithelial cells which are known to contain ornithine decarboxylase. The probes also located squamous cell carcinoma cells in human skin.
last changed 2002/11/12 16:17

B6db references