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B6db references: 92307691

type Journal Article
authors Scherer, L. J.; McPherson, J. D.; Wasmuth, J. J.; Marsh, J. L.
title Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs
journal Genomics
ui 92307691
year (1992)
volume 13
number 2
pages 469-71.
keywords Animal
abstract We have cloned full-length DDC cDNAs from a human hepatoma cDNA library [DDC; dopa decarboxylase; aromatic-L-amino acid decarboxylase, EC]. The protein encoded by hepatoma cells is the same as that encoded by adrenal chromaffin derived pheochromocytoma cells, despite reported differences in biochemical properties. We have confirmed the location of the DDC gene to chromosome 7 using a new panel of somatic cell hybrids, and we have localized the gene to band p11 on chromosome 7 by fluorescent in situ hybridization. The human gene retains 65% amino acid identity with Drosophila DDC (Accession No. X04426) and considerable structural similarity with other enzymes (F.R. Jackson, 1990, J. Mol. Evol. 31:325-329, and references therein).
last changed 2002/11/12 16:17

B6db references