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B6db references: 93260457

type Journal Article
authors Hadjiconstantinou, M.; Wemlinger, T. A.; Sylvia, C. P.; Hubble, J. P.; Neff, N. H.
title Aromatic L-amino acid decarboxylase activity of mouse striatum is modulated via dopamine receptors
journal J Neurochem
ui 93260457
year (1993)
volume 60
number 6
pages 2175-80.
keywords 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*pharmacology
abstract Aromatic L-amino acid decarboxylase (AAAD) activity is enhanced in the striatum of control and MPTP-treated mice after administration of a single dose of the dopamine receptor antagonists haloperidol, sulpiride, and SCH 23390. MPTP-treated mice appear more sensitive to the antagonists, i.e., respond earlier and to lower doses of antagonists than control mice. The rise of AAAD activity induced by the antagonists is prevented by pretreatment with cycloheximide. The apparent Km values for L-3,4-dihydroxyphenylalanine (L-DOPA) and pyridoxal 5-phosphate appear unchanged after treatment with the antagonists. Increased AAAD activity was observed also after subchronic administration of dopamine receptor antagonists or treatment with reserpine. A single dose of a selective dopamine receptor agonists had no effect on AAAD activity. In contrast, administration of L-DOPA, quinpirole, or SKF 23390 for 7 days lowers AAAD activity in the striatum. We conclude that AAAD is modulated in striatum via dopaminergic receptors.
last changed 2002/11/12 16:17

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