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B6db references: 94010910

type Journal Article
authors Oda, T.; Nishiyama, K.; Ichiyama, A.
title Characterization and sequence analysis of rat serine:pyruvate/alanine:glyoxylate aminotransferase gene
journal Genomics
sel unselected
ui 94010910
year (1993)
volume 17
number 1
pages 59-65.
keywords Alanine Transaminase/*genetics
abstract We have reported the isolation of genomic clones encoding serine:pyruvate aminotransferase (SPT; also named alanine:glyoxylate aminotransferase, AGT) (T. Oda, T. Funai, and A. Ichiyama, 1990, J. Biol. Chem. 265: 7513-7519). These clones contained the entire SPT/AGT gene of 10 kb. In this work, we characterized this gene. The SPT/AGT gene consists of 11 exons, and the exon-intron boundaries have typical splice donor and acceptor sequences. Determination of the nucleotide sequence up to -1.25 kb from the transcription initiation site revealed the presence of many putative cis elements, some of which may explain the transcriptional regulation of the SPT/AGT gene by glucagon and glucocorticoid. The nucleotide sequence around the 5' flanking region of the rat SPT/AGT gene and the whole gene organization were compared with those of the human SPT/AGT gene. No obvious similarities were observed in the 5' flanking region up to -1.25 kb from the initiation site of the gene, but exons 2 to 10 of the rat and human genes have identical sizes and show high similarities.
last changed 2004/02/13 15:51

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