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B6db references: 94121622

type Journal Article
authors Mehta, P. K.; Christen, P.
title Homology of 1-aminocyclopropane-1-carboxylate synthase, 8-amino-7- oxononanoate synthase, 2-amino-6-caprolactam racemase, 2,2- dialkylglycine decarboxylase, glutamate-1-semialdehyde 2,1-aminomutase and isopenicillin-N-epimerase with aminotransferases
journal Biochem Biophys Res Commun
ui 94121622
year (1994)
volume 198
number 1
pages 138-43.
keywords Acyltransferases/*chemistry
abstract Profile analysis showed the title enzymes to be homologous with the aminotransferases. 1-Aminocyclopropane-1-carboxylate synthase is closely related to subgroup I of aminotransferases which includes aspartate, alanine, histidinol-phosphate, tyrosine and phenylalanine aminotransferase. 2,2-Dialkylglycine decarboxylase, glutamate-1- semialdehyde 2,1-aminomutase and 2-amino-6-caprolactam racemase are most similar to subgroup II which comprises aminotransferases with omega-amino acids as substrates. 8-Amino-7-oxononanoate synthase is closely related to both subgroup I and II, and isopenicillin-N- epimerase to subgroup IV with serine and phosphoserine aminotransferase. Aminotransferases and the title enzymes belong to a regio-specific family of evolutionarily related pyridoxal-5'-phosphate- dependent enzymes.
last changed 2002/11/12 16:17

B6db references