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B6db references: 95204430

type Journal Article
authors Bao, J.; Cheung, W. Y.; Wu, J. Y.
title Brain L-glutamate decarboxylase. Inhibition by phosphorylation and activation by dephosphorylation
journal J Biol Chem
ui 95204430
year (1995)
volume 270
number 12
pages 6464-7.
keywords Animal
abstract Previously we showed that the activity of the gamma-aminobutyric acid- synthesizing enzyme L-glutamate decarboxylase (GAD) in crude brain extract is inhibited by ATP and protein phosphatase inhibitors. We suggested that GAD activity is regulated by protein phosphorylation. In this paper we further present evidence to support our hypothesis that protein kinase A and calcineurin may be involved in regulation of GAD activity through phosphorylation and dephosphorylation fo GAD, respectively. In addition, the effect of neuronal stimulation on GAD activity in cultured neurons is also included. A model to link neuronal excitation and activation of GAD by Ca(2+)-dependent phosphatase is proposed.
last changed 2002/11/12 16:17

B6db references