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B6db references: 97263786

type Journal Article
authors Topczewski, J.; Sienko, M.; Paszewski, A.
title Cloning and characterization of the Aspergillus nidulans cysB gene encoding cysteine synthase
journal Curr Genet
sel unselected
ui 97263786
year (1997)
volume 31
number 4
pages 348-56.
keywords Amino Acid Sequence
abstract The cysB gene of A. nidulans was cloned by complementation of a cysB mutation. This is the first cloned eukaryotic genomic sequence coding for cysteine synthase. The gene contains one 71-bp intron and codes for a protein of 370 amino acids. Its N-terminal region has characteristic features of transit peptides, suggesting mitochondrial localisation of the enzyme. The protein shows homology with bacterial and plant cysteine synthases among which it occupies a remote phylogenetic position and apparently represents a distinct subfamily. Transcription of the cysB gene is not appreciably regulated by the concentration of methionine in the growth medium.
last changed 2003/11/13 10:48

B6db references