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B6db references: 11566853

type Journal Article
authors Li, G.; Foote, C.; Alexander, S.; Alexander, H.
title Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum
journal Development
sel selected
ui 11566853
year (2001)
volume 128
number 18
pages 3473-83
keywords Aldehyde-Lyases/genetics/*physiology
abstract Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element of signal transduction pathways that regulate cell proliferation and cell death. We have demonstrated additional roles for sphingosine-1-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme that catalyzes sphingosine-1-phosphate degradation, results in a mutant strain with aberrant morphogenesis, as well as an increase in viability during stationary phase. The absence of sphingosine-1-phosphate lyase affects multiple stages throughout development, including the cytoskeletal architecture of aggregating cells, the ability to form migrating slugs, and the control of cell type-specific gene expression and terminal spore differentiation. This pleiotropic effect, which is due to the loss of sphingosine-1-phosphate lyase, establishes sphingolipids as pivotal regulatory molecules in a wide range of processes in multicellular development.
last changed 2009/06/23 09:14

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