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B6db references: 12235163

type Journal Article
authors Kuettner, E.; Hilgenfeld, R.; Weiss, M. S.
title The active principle of garlic at atomic resolution
journal J Biol Chem
Activity 4.4.1.4
Family 4.4.1.4
sel selected
ui 12235163
year (2002)
volume 277
number 48
pages 46402-7
 
keywords Amino Acid Sequence
abstract Despite the fact that many cultures around the world value and utilize garlic as a fundamental component of their cuisine as well as of their medicine cabinets, relatively little is known about the plant's protein configuration that is responsible for the specific properties of garlic. Here, we report the three-dimensional structure of the garlic enzyme alliinase at 1.5 A resolution. Alliinase constitutes the major protein component in garlic bulbs, and it is able to cleave carbon-sulfur bonds. The active enzyme is a pyridoxal-5'-phosphate-dependent homodimeric glycoprotein and belongs to the class I family of pyridoxal-5'-phosphate-dependent enzymes. In addition, it contains a novel epidermal growth factor-like domain that makes it unique among all pyridoxal-5'-phosphate-dependent enzymes.
last changed 2009/07/01 10:48

B6db references