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B6db references: 20133766

type Journal Article
authors Kim PM, Duan X, Huang AS, Liu CY, Ming GL, Song H, Snyder SH
title Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis
journal Proc Natl Acad Sci U S A
Activity 5.1.1.13
Family 5.1.1.13.a
sel selected
ui 20133766
year (2010)
volume 107
number 7
pages 3175-9
 
abstract D-aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development and survival of newborn neurons and survival. Because D-aspartate is a potential endogenous ligand for NMDA receptors, the loss of which elicits a phenotype resembling DR depletion, D-aspartate may function as a modulator of adult neurogenesis.
last changed 2010/06/14 11:09

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